| Drug Category |
Large1 increase - CYP3A2 |
Moderate1 increase - CYP2D62 |
Moderate1 increase or decrease - CYP2C9/192 |
Possible increase - unknown CYP2 |
Possible decrease - glucuronidation2 |
| Analgesics, narcotic |
alfentanil
(Alfentatm)
fentanyl (Duragesic Transdermal Systemtm) |
hydrocodone (Lorcettm,
Lortabtm,
Vicodintm;
for pain and
also severe
coughing)
oxycodone (Percodantm) tramadol |
|
methadone (Dolophinetm) | codeine
(Tylenol
#3tm,
Empirintm,
Tussi-Organidintm)
hydromorphone morphine |
| Analgesics, nonsteroidal |
|
|
diclofenac
(Voltarentm)
ibuprofen (Adviltm, Motrintm) indomethacin (Indocintm) |
nabumetone
sulindac (Clinoriltm, Sulindactm) |
ketoprofen
(Orudistm)
ketorolac (Toradoltm) naproxen (Naprosyntm, Alevetm) |
| Antiarrhythmics (acts to control or prevent cardiac arrhythmias [irregularity or loss of rhythm]) | disopyramide
lidocaine |
mexiletine (Mexitiltm, for neuropathy) |
|
tocainide
digoxin |
|
| Antibiotic,
macrolide |
erythromycin |
|
|
|
|
| Anticoagulant (blood thinners) | R-warfarin |
|
S-warfarin |
|
|
| Anticonvulsants | carbamazepine
(Tegretoltm,
sometimes
used for
peripheral
neuropathy)
clonazepam (Klonopintm, for seizures - including those from toxoplasmosis) ethosuximide (Zarontintm) |
|
phenytoin (Dilantintm) | phenobarbital | divalproex
(Depakotetm)
lamotrigine (Lamictaltm) |
| Antihistamine | loratidine (Claritintm) |
|
|
|
|
| Antidepressants, tricyclic |
|
amitriptyline (Elaviltm)
clomipramine (Anafraniltm) desipramine (Desipraminetm) imipramine (Imipraminetm, Janiminetm, Tofraniltm) maprotiline (Ludiomiltm | )
|
doxepin (Doxepintm, Sinequantm) |
|
| Antidepressants, other | nefazodone
(Serzonetm)
sertraline (Zolofttm) trazodone (Desyreltm) |
fluoxetine
(Prozactm)
paroxetine (Paxiltm) venlafaxine (Effexortm) |
|
fluvoxamine (Luvoxtm) |
|
| Antidiarrheal |
|
|
|
|
diphenoxylate (Lomotiltm) |
| Antiemetics (preventing or relieving nausea and vomiting) | dronabinol
(Marinoltm)
ondansetron (Zofrantm, for nausea) |
|
|
prochlorperazine
(Compazinetm, for
nausea)
promethazine (Phenergantm, antihistamine/ antiemetic/ sedative) |
metoclopramide (Clopratm, Reglantm) |
| Antifungal agents |
|
|
|
itraconazole
(Sporonoxtm)
ketoconazole (Nizoraltm) miconazole (Monistattm) |
|
| Antihypertinsives |
|
|
losartan | doxazosin
(Carduratm)
prazosin (Prazosintm, Minipresstm, Minizidetm) terazosin (Hytrintm) |
|
| Antimycobacterial (Mycobacterium is a genus of organisms that includes what causes TB) | rifampin (used in combination with other drugs for TB and MAC) |
|
|
|
|
| Antiparasitics (destroys parasites - organisms that live within, upon or at expense of another organism, known as the host) | quinine |
|
proguanil | albendazole
chloroquine (Aralentm, Chloroquinetm) metronidazole (Flagyltmantibiotic/ antiprotozoal/ antifungal. May work for microsporidiosis) primaquine (Primaquinetm, for malaria) pyrimethamine (Daraprimtm |
atovaquone (Meprontm, for PCP, toxoplasmosis, microsporidiosis) |
| Antiulcer agents |
|
|
lansoprazole
omeprazole (Prilosectm) |
cimetidine (Tagamettm) |
|
| Beta blockers (substances that interfere with the transmission of stimuli...used in treating hypertension, heart problems, stage fright & benign tremors) |
|
metoprolol
(Lopressortm)
pindolol (Viskentm) propranolol (Inderaltm, Inderidetm, can be used for anxiety) timolol |
|
acebutolol
(Sectraltm)
betaxolol (Betoptictm, Kerlonetm) penbutolol (Levatoltm) |
|
| Calcium channel blockers (act by slowing the influx of calcium into muscle cells, resulting in decreased oxygen demand by the heart -- treatment for angina hypertension) | amlodipine
diltiazem (Cardizemtm) felodipine (Plendiltm) isradipine (DynaCirctm) nicardipine (Cardenetm) nifedipine (Adalattm, Nifedipinetm, Procardiatm |
|
|
|
|
| Cancer chemotherapeutic agents | etoposide
(VePesidtm,
used in
trials for
KS, CMV)
paclitaxel (Taxoltm, trials for KS) tamoxifen vinblastine (Velbantm, for KS) vincristine (Oncovintm, for KS) |
|
|
cyclophosphamide
(Cyclophosphamidetm,
Cytoxantm,
Neosartm)
daunorubicin (Cerubidinetm, liposomal form for KS) doxorubicin (Adriamycintm, in combination with other drugs for KS; liposomal form DOX-SL |
|
| Corticosteroids | dexamethasone
(Decadrontm)
prednisone (used for, among other things, reducing lung inflammation in PCP) |
|
|
|
|
| Hemorrheologic agent |
|
|
|
pentoxifylline (Trentaltm, possible immune-based anti-HIV therapy) |
|
| HIV protease inhibitors | saquinavir (Invirasetm) |
|
|
|
|
| Hypoglycemics (pertaining to sugar deficiencies) |
|
|
glipizide
(Glucotroltm)
glyburide (DiaBetatm, Micronasetm) tolbutamide (Orinasetm, Tolbutamidetm) |
|
|
| Hypolipidemics (decreasing the lipid [fat] concentration of the blood) | lovastatin
(Mevacortm)
pravastatin (Pravacholtm) |
|
|
fluvastatin
(Lescoltm)
gemfibrozil (Lopidtm) simvastatin (Zocortm) |
clofibrate (Atromid-Stm) |
| Immunosuppresants | cyclosporine
(Sandimmunetm)
tacrolimus |
|
|
|
|
| Neuroleptics ("an agent or drug that modifies psychotic behavior") |
|
chlorpromazine
(Chlorpromazinetm,
Thorazinetm)
laloperidol perphenazine (Trilafontm, psychoactive - antinausea, antivomiting, antipsychosis) risperidone (Risperdaltm) thioridazine (Mellariltm, Mellarzinetm |
|
|
|
| Sedative/hypnotics |
|
|
|
|
lorazepam
(Ativantm,
psychoactive
tranquilizer)
oxazepam (Seraxtm, for anxiety) propofol temazepam (Restoriltm, psychoactive sedative) |
| Stimulants |
|
methamphetamine (Desoxyntm) |
|
methylphenidate (Ritalintm, psychoactive stimulant) |
|
1Large=> 3X. Moderate = 1.5X-3X
2Increased or decreased drug exposure (technically, the "area under the plasma concentration time curve," or "AUC") to this metabolizing agent. Increased AUC means that -- when on ritonavir -- there is more of this other drug in the blood. More drug in the blood means it is not being metabolized normally. This can lead to toxicities or increased side effects as a result. (Just the opposite can happen when there is decreased AUC: The drug may be being metabolized too quickly to be effective.)
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